The Cytoplasmic Domain of A Disintegrin and Metalloproteinase 10 (ADAM10) Regulates Its Constitutive Activity but Is Dispensable for Stimulated ADAM10-dependent Shedding

The membrane-anchored metalloproteinase a disintegrin and metalloprotease 10 (ADAM10) is required for shedding of membrane proteins such as EGF, betacellulin, the amyloid precursor protein, and CD23 from cells. ADAM10 is constitutively active and can be rapidly and post-translationally enhanced by s...

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Foilsithe in:J Biol Chem
Main Authors: Maretzky, Thorsten, Evers, Astrid, Le Gall, Sylvain, Alabi, Rolake O., Speck, Nancy, Reiss, Karina, Blobel, Carl P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2015
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367251/
https://ncbi.nlm.nih.gov/pubmed/25605720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.603753
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