Incidence and relevance of QTc-interval prolongation caused by tyrosine kinase inhibitors

BACKGROUND: Tyrosine kinase inhibitors (TKIs) are associated with prolongation of the QTc interval on the electrocardiogram (ECG). The QTc-interval prolongation increases the risk of life-threatening arrhythmias. However, studies evaluating the effects of TKIs on QTc intervals are limited and only c...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Kloth, J S L, Pagani, A, Verboom, M C, Malovini, A, Napolitano, C, Kruit, W H J, Sleijfer, S, Steeghs, N, Zambelli, A, Mathijssen, R H J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366905/
https://ncbi.nlm.nih.gov/pubmed/25742483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.82
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