High-Throughput Screening Platform Identifies Small Molecules That Prevent Sequestration of Plasmodium falciparum–Infected Erythrocytes

Background. We developed a 2-step approach to screen molecules that prevent and/or reverse Plasmodium falciparum–infected erythrocyte (IE) binding to host receptors. IE adhesion and sequestration in vasculature causes severe malaria, and therefore antiadhesion therapy might be useful as adjunctive t...

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Veröffentlicht in:J Infect Dis
Hauptverfasser: Gullingsrud, Justin, Milman, Neta, Saveria, Tracy, Chesnokov, Olga, Williamson, Kathryn, Srivastava, Anand, Gamain, Benoit, Duffy, Patrick E., Oleinikov, Andrew V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
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Major Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366606/
https://ncbi.nlm.nih.gov/pubmed/25355939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu589
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