Gp78, an E3 Ubiquitin Ligase Acts as a Gatekeeper Suppressing Nonalcoholic Steatohepatitis (NASH) and Liver Cancer

Nonalcoholic steatohepatitis (NASH) is related to metabolic dysregulation and the perturbation of endoplasmic reticulum (ER) homeostasis that frequently develops into hepatocellular carcinoma (HCC). Gp78 is E3 ligase, which regulates endoplasmic reticulum-associated degradation (ERAD) by ubiquitinyl...

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Vydáno v:PLoS One
Hlavní autoři: Zhang, Tianpeng, Kho, Dhong Hyo, Wang, Ying, Harazono, Yosuke, Nakajima, Kosei, Xie, Youming, Raz, Avraham
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366401/
https://ncbi.nlm.nih.gov/pubmed/25789613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118448
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