Development and Characterization of Recombinant Antibody Fragments That Recognize and Neutralize In Vitro Stx2 Toxin from Shiga Toxin-Producing Escherichia coli

BACKGROUND: Stx toxin is a member of the AB(5) family of bacterial toxins: the active A subunit has N-glycosidase activity against 28S rRNA, resulting in inhibition of protein synthesis in eukaryotic cells, and the pentamer ligand B subunits (StxB) bind to globotria(tetra)osylceramide receptors (Gb3...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Luz, Daniela, Chen, Gang, Maranhão, Andrea Q., Rocha, Leticia B., Sidhu, Sachdev, Piazza, Roxane M. F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366190/
https://ncbi.nlm.nih.gov/pubmed/25790467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120481
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