Molecular Interaction of a Kinase Inhibitor Midostaurin with Anticancer Drug Targets, S100A8 and EGFR: Transcriptional Profiling and Molecular Docking Study for Kidney Cancer Therapeutics

The S100A8 and epidermal growth factor receptor (EGFR) proteins are proto-oncogenes that are strongly expressed in a number of cancer types. EGFR promotes cellular proliferation, differentiation, migration and survival by activating molecular pathways. Involvement of proinflammatory S100A8 in tumor...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mirza, Zeenat, Schulten, Hans-Juergen, Farsi, Hasan Ma, Al-Maghrabi, Jaudah A., Gari, Mamdooh A., Chaudhary, Adeel Ga, Abuzenadah, Adel M., Al-Qahtani, Mohammed H., Karim, Sajjad
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366044/
https://ncbi.nlm.nih.gov/pubmed/25789858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119765
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