N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.

GGA to GAA mutations in the 12th codon of the Hras gene are frequently observed in rat mammary tumors induced by N-nitroso-N-methylurea (NMU). We developed an assay to measure point mutations present in tissues at a frequency of 10(-5) and have now applied this assay to measure the specific G to A t...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Cha, R S, Thilly, W G, Zarbl, H
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43659/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8170982/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.9.3749
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