Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization.

We describe a general strategy for cloning mammalian genes whose downregulation results in a selectable phenotype. This strategy is based on expression selection of genetic suppressor elements (GSEs), cDNA fragments encoding either specific peptides that act as dominant inhibitors of protein functio...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Gudkov, A V, Kazarov, A R, Thimmapaya, R, Axenovich, S A, Mazo, I A, Roninson, I B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43658/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8170981/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.9.3744
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