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Pancancer analysis of DNA methylation-driven genes using MethylMix

Aberrant DNA methylation is an important mechanism that contributes to oncogenesis. Yet, few algorithms exist that exploit this vast dataset to identify hypo- and hypermethylated genes in cancer. We developed a novel computational algorithm called MethylMix to identify differentially methylated gene...

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Détails bibliographiques
Publié dans:Genome Biol
Auteurs principaux: Gevaert, Olivier, Tibshirani, Robert, Plevritis, Sylvia K
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365533/
https://ncbi.nlm.nih.gov/pubmed/25631659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0579-8
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