A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females

Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays a strong female bias. By performing a genome-wide association study (GWAS) of 3,102 individuals, we identify significant associations with 20p11.22 SNPs for females (P=6.89 × 10(−9)) but not males (P=0.71). This a...

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Publicado no:Nat Commun
Main Authors: Sharma, Swarkar, Londono, Douglas, Eckalbar, Walter L., Gao, Xiaochong, Zhang, Dongping, Mauldin, Kristen, Kou, Ikuyo, Takahashi, Atsushi, Matsumoto, Morio, Kamiya, Nobuhiro, Murphy, Karl K., Cornelia, Reuel, Herring, John A., Burns, Dennis, Ahituv, Nadav, Ikegawa, Shiro, Gordon, Derek, Wise, Carol A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365504/
https://ncbi.nlm.nih.gov/pubmed/25784220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7452
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