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ICAM-5 affects spine maturation by regulation of NMDA receptor binding to α-actinin

ICAM-5 is a negative regulator of dendritic spine maturation and facilitates the formation of filopodia. Its absence results in improved memory functions, but the mechanisms have remained poorly understood. Activation of NMDA receptors induces ICAM-5 ectodomain cleavage through a matrix metalloprote...

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Podrobná bibliografie
Vydáno v:Biol Open
Hlavní autoři: Ning, Lin, Paetau, Sonja, Nyman-Huttunen, Henrietta, Tian, Li, Gahmberg, Carl G.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365481/
https://ncbi.nlm.nih.gov/pubmed/25572420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.201410439
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