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Addressing the Challenges of Low Clearance in Drug Research
As a result of high-throughput ADME screening, early metabolite identification, and exploration of novel chemical entities, low-intrinsic-clearance compounds continue to increase in drug discovery portfolios. Currently available in vitro tools have limited resolution below a certain intrinsic cleara...
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| Veröffentlicht in: | AAPS J |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer US
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4365098/ https://ncbi.nlm.nih.gov/pubmed/25567366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9691-7 |
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