Epithelial Cell Mitochondrial Dysfunction and PINK1 Are Induced by Transforming Growth Factor- Beta1 in Pulmonary Fibrosis

BACKGROUND: Epithelial cell death is a major contributor to fibrogenesis in the lung. In this study, we sought to determine the function of mitochondria and their clearance (mitophagy) in alveolar epithelial cell death and fibrosis. METHODS: We studied markers of mitochondrial injury and the mitopha...

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Pubblicato in:PLoS One
Autori principali: Patel, Avignat S., Song, Jin Woo, Chu, Sarah G., Mizumura, Kenji, Osorio, Juan C., Shi, Ying, El-Chemaly, Souheil, Lee, Chun Geun, Rosas, Ivan O., Elias, Jack A., Choi, Augustine M. K., Morse, Danielle
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364993/
https://ncbi.nlm.nih.gov/pubmed/25785991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121246
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