Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance

Pattern recognition receptors link metabolite and bacteria-derived inflammation to insulin resistance during obesity. We demonstrate that NOD2 detection of bacterial cell wall peptidoglycan (PGN) regulates metabolic inflammation and insulin sensitivity. An obesity-promoting high-fat diet (HFD) incre...

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Publicat a:EMBO Mol Med
Autors principals: Denou, Emmanuel, Lolmède, Karine, Garidou, Lucile, Pomie, Celine, Chabo, Chantal, Lau, Trevor C, Fullerton, Morgan D, Nigro, Giulia, Zakaroff-Girard, Alexia, Luche, Elodie, Garret, Céline, Serino, Matteo, Amar, Jacques, Courtney, Michael, Cavallari, Joseph F, Henriksbo, Brandyn D, Barra, Nicole G, Foley, Kevin P, McPhee, Joseph B, Duggan, Brittany M, O'Neill, Hayley M, Lee, Amanda J, Sansonetti, Philippe, Ashkar, Ali A, Khan, Waliul I, Surette, Michael G, Bouloumié, Anne, Steinberg, Gregory R, Burcelin, Rémy, Schertzer, Jonathan D
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2015
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364944/
https://ncbi.nlm.nih.gov/pubmed/25666722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404169
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