Phagocytosis-dependent activation of a TLR9–BTK–calcineurin–NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus

Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining risk of infection. Here, we show that the calcineurin inhibitor tacrolimus impairs clearance of the major moul...

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Bibliografiske detaljer
Udgivet i:EMBO Mol Med
Main Authors: Herbst, Susanne, Shah, Anand, Mazon Moya, Maria, Marzola, Vanessa, Jensen, Barbara, Reed, Anna, Birrell, Mark A, Saijo, Shinobu, Mostowy, Serge, Shaunak, Sunil, Armstrong-James, Darius
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2015
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364943/
https://ncbi.nlm.nih.gov/pubmed/25637383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404556
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