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Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome–lysosome fusion

Autophagy, the process for recycling cytoplasm in the lysosome, depends on membrane trafficking. We previously identified Drosophila Sbf as a Rab21 guanine nucleotide exchange factor (GEF) that acts with Rab21 in endosomal trafficking. Here, we show that Sbf/MTMR13 and Rab21 have conserved functions...

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Publicat a:EMBO Rep
Autors principals: Jean, Steve, Cox, Sarah, Nassari, Sonya, Kiger, Amy A
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364869/
https://ncbi.nlm.nih.gov/pubmed/25648148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439464
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