Dystrophic Spinal Deformities in a Neurofibromatosis Type 1 Murine Model

Despite the high prevalence and significant morbidity of spinal anomalies in neurofibromatosis type 1 (NF1), the pathogenesis of these defects remains largely unknown. Here, we present two murine models: Nf1(flox/−);PeriCre and Nf1(flox/−);Col.2.3Cre mice, which recapitulate spinal deformities seen...

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Vydáno v:PLoS One
Hlavní autoři: Rhodes, Steven D., Zhang, Wei, Yang, Dalong, Yang, Hao, Chen, Shi, Wu, Xiaohua, Li, Xiaohong, Yang, Xianlin, Mohammad, Khalid S., Guise, Theresa A., Bergner, Amanda L., Stevenson, David A., Yang, Feng-Chun
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364663/
https://ncbi.nlm.nih.gov/pubmed/25786243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119093
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