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Memantine block depends on agonist presentation at the NMDA receptor in substantia nigra pars compacta dopamine neurones
NMDA glutamate receptors (NMDARs) have critical functional roles in the nervous system but NMDAR over-activity can contribute to neuronal damage. The open channel NMDAR blocker, memantine is used to treat certain neurodegenerative diseases, including Parkinson’s disease (PD) and is well tolerated cl...
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| Veröffentlicht in: | Neuropharmacology |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4363981/ https://ncbi.nlm.nih.gov/pubmed/23727219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2013.05.013 |
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