Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons

It remains a challenge to differentiate human induced pluripotent stem cells (iPSCs) or embryonic stem (ES) cells to Purkinje cells. In this study, we derived iPSCs from human fibroblasts and directed the specification of iPSCs first to Purkinje progenitors, by adding Fgf2 and insulin to the embryoi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wang, Shuyan, Wang, Bin, Pan, Na, Fu, Linlin, Wang, Chaodong, Song, Gongru, An, Jing, Liu, Zhongfeng, Zhu, Wanwan, Guan, Yunqian, Xu, Zhi-Qing David, Chan, Piu, Chen, Zhiguo, Zhang, Y. Alex
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363833/
https://ncbi.nlm.nih.gov/pubmed/25782665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09232
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