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Obatoclax Regulates the Proliferation and Fusion of Osteoclast Precursors through the Inhibition of ERK Activation by RANKL

Obatoclax, a pan-Bcl2 inhibitor, shows antitumor activities in various solid malignancies. Bcl2-deficient mice have shown the importance of Bcl2 in osteoclasts, as the bone mass of the mice was increased by the induced apoptosis of osteoclasts. Despite the importance of Bcl2, the effects of obatocla...

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Detalhes bibliográficos
Publicado no:Mol Cells
Main Authors: Oh, Ju Hee, Lee, Jae Yoon, Park, Jin Hyeong, No, Jeong Hyeon, Lee, Na Kyung
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Molecular and Cellular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363729/
https://ncbi.nlm.nih.gov/pubmed/25666350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2015.2340
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