Disrupting Protein Expression with Peptide Nucleic Acids Reduces Infection by Obligate Intracellular Rickettsia

Peptide Nucleic Acids (PNAs) are single-stranded synthetic nucleic acids with a pseudopeptide backbone in lieu of the phosphodiester linked sugar and phosphate found in traditional oligos. PNA designed complementary to the bacterial Shine-Dalgarno or start codon regions of mRNA disrupts translation...

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Udgivet i:PLoS One
Main Authors: Pelc, Rebecca S., McClure, Jennifer C., Kaur, Simran J., Sears, Khandra T., Rahman, M. Sayeedur, Ceraul, Shane M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363562/
https://ncbi.nlm.nih.gov/pubmed/25781160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119283
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