CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells

BACKGROUND: The histone H3 variant CENP-A is normally tightly regulated to ensure only one centromere exists per chromosome. Native CENP-A is often found overexpressed in human cancer cells and a range of human tumors. Consequently, CENP-A misregulation is thought to contribute to genome instability...

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Bibliografske podrobnosti
izdano v:Epigenetics Chromatin
Main Authors: Athwal, Rajbir K, Walkiewicz, Marcin P, Baek, Songjoon, Fu, Song, Bui, Minh, Camps, Jordi, Ried, Thomas, Sung, Myong-Hee, Dalal, Yamini
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363203/
https://ncbi.nlm.nih.gov/pubmed/25788983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-8-2
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