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CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells
BACKGROUND: The histone H3 variant CENP-A is normally tightly regulated to ensure only one centromere exists per chromosome. Native CENP-A is often found overexpressed in human cancer cells and a range of human tumors. Consequently, CENP-A misregulation is thought to contribute to genome instability...
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Publicado no: | Epigenetics Chromatin |
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Main Authors: | , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BioMed Central
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4363203/ https://ncbi.nlm.nih.gov/pubmed/25788983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-8-2 |
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