Metformin Does not Reduce Markers of Cell Proliferation in Esophageal Tissues of Patients with Barrett's Esophagus

BACKGROUND & AIMS: Obesity is associated with neoplasia, possibly via insulin-mediated cell pathways that affect cell proliferation. Metformin has been proposed to protect against obesity-associated cancers by decreasing serum insulin. We conducted a randomized, double-blind, placebo-controlled,...

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Detalhes bibliográficos
Publicado no:Clin Gastroenterol Hepatol
Main Authors: Chak, Amitabh, Buttar, Navtej S., Foster, Nathan R., Seisler, Drew K., Marcon, Norman E., Schoen, Robert, Cruz-Correa, Marcia R., Falk, Gary W., Sharma, Prateek, Hur, Chin, Katzka, David A., Rodriguez, Luz M., Richmond, Ellen, Sharma, Anamay N., Smyrk, Thomas C., Mandrekar, Sumithra J., Limburg, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362887/
https://ncbi.nlm.nih.gov/pubmed/25218668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cgh.2014.08.040
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