DOSAGE-DEPENDENT REGULATION OF PANCREATIC CANCER GROWTH AND ANGIOGENESIS BY HEDGEHOG SIGNALING

Pancreatic cancer, a hypovascular and highly desmoplastic cancer, is characterized by tumor expression of Hedgehog (HH) ligands which signal to fibroblasts in the surrounding stroma that in turn promote tumor survival and growth. However, the mechanisms and consequences of stromal HH pathway activat...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Mathew, Esha, Zhang, Yaqing, Holtz, Alexander M., Kane, Kevin T., Song, Jane Y., Allen, Benjamin L., Pasca di Magliano, Marina
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362534/
https://ncbi.nlm.nih.gov/pubmed/25310976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.09.010
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