DOSAGE-DEPENDENT REGULATION OF PANCREATIC CANCER GROWTH AND ANGIOGENESIS BY HEDGEHOG SIGNALING

Pancreatic cancer, a hypovascular and highly desmoplastic cancer, is characterized by tumor expression of Hedgehog (HH) ligands which signal to fibroblasts in the surrounding stroma that in turn promote tumor survival and growth. However, the mechanisms and consequences of stromal HH pathway activat...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Mathew, Esha, Zhang, Yaqing, Holtz, Alexander M., Kane, Kevin T., Song, Jane Y., Allen, Benjamin L., Pasca di Magliano, Marina
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362534/
https://ncbi.nlm.nih.gov/pubmed/25310976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.09.010
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