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DOSAGE-DEPENDENT REGULATION OF PANCREATIC CANCER GROWTH AND ANGIOGENESIS BY HEDGEHOG SIGNALING
Pancreatic cancer, a hypovascular and highly desmoplastic cancer, is characterized by tumor expression of Hedgehog (HH) ligands which signal to fibroblasts in the surrounding stroma that in turn promote tumor survival and growth. However, the mechanisms and consequences of stromal HH pathway activat...
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| Published in: | Cell Rep |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4362534/ https://ncbi.nlm.nih.gov/pubmed/25310976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.09.010 |
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