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Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves

AIMS: The mesenchymal cushions lining the early embryonic heart undergo complex remodelling to form the membranous ventricular septum as well as the atrioventricular and semilunar valves in later life. Disruption of this process underlies the most common congenital heart defects. Here, we identified...

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Publicado en:Cardiovasc Res
Autores principales: Mommersteeg, Mathilda T.M., Yeh, Mason L., Parnavelas, John G., Andrews, William D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362403/
https://ncbi.nlm.nih.gov/pubmed/25691540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv040
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