Preclinical efficacy and safety of an anti-IL-1β vaccine for the treatment of type 2 diabetes

Neutralization of the inflammatory cytokine interleukin-1β (IL-1β) is a promising new strategy to prevent the β-cell destruction, which leads to type 2 diabetes. Here, we describe the preclinical development of a therapeutic vaccine against IL-1β consisting of a detoxified version of IL-1β chemicall...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Spohn, Gunther, Schori, Christian, Keller, Iris, Sladko, Katja, Sina, Christina, Guler, Reto, Schwarz, Katrin, Johansen, Pål, Jennings, Gary T, Bachmann, Martin F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362373/
https://ncbi.nlm.nih.gov/pubmed/26015986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.48
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