Magnitude of the Benefit of Progression-Free Survival as a Potential Surrogate Marker in Phase 3 Trials Assessing Targeted Agents in Molecularly Selected Patients with Advanced Non-Small Cell Lung Cancer: Systematic Review

BACKGROUND: In evaluation of the clinical benefit of a new targeted agent in a phase 3 trial enrolling molecularly selected patients with advanced non-small cell lung cancer (NSCLC), overall survival (OS) as an endpoint seems to be of limited use because of a high level of treatment crossover for et...

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Bibliographic Details
Published in:PLoS One
Main Authors: Hotta, Katsuyuki, Kato, Yuka, Leighl, Natasha, Takigawa, Nagio, Gaafar, Rabab Mohamed, Kayatani, Hiroe, Hirata, Taizo, Ohashi, Kadoaki, Kubo, Toshio, Tabata, Masahiro, Tanimoto, Mitsune, Kiura, Katsuyuki
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361736/
https://ncbi.nlm.nih.gov/pubmed/25775395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121211
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