Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Requires CADM1/TSLC1 for Inactivation of the NF-κB Inhibitor A20 and Constitutive NF-κB Signaling

Persistent activation of NF-κB by the Human T-cell leukemia virus type 1 (HTLV-1) oncoprotein, Tax, is vital for the development and pathogenesis of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). K63-linked polyubiquitinated Tax activates the IKK...

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Udgivet i:PLoS Pathog
Main Authors: Pujari, Rajeshree, Hunte, Richard, Thomas, Remy, van der Weyden, Louise, Rauch, Dan, Ratner, Lee, Nyborg, Jennifer K., Ramos, Juan Carlos, Takai, Yoshimi, Shembade, Noula
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361615/
https://ncbi.nlm.nih.gov/pubmed/25774694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004721
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