Linking Aβ42-Induced Hyperexcitability to Neurodegeneration, Learning and Motor Deficits, and a Shorter Lifespan in an Alzheimer’s Model

Alzheimer’s disease (AD) is the most prevalent form of dementia in the elderly. β-amyloid (Aβ) accumulation in the brain is thought to be a primary event leading to eventual cognitive and motor dysfunction in AD. Aβ has been shown to promote neuronal hyperactivity, which is consistent with enhanced...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Ping, Yong, Hahm, Eu-Teum, Waro, Girma, Song, Qian, Vo-Ba, Dai-An, Licursi, Ashley, Bao, Han, Ganoe, Logan, Finch, Kelly, Tsunoda, Susan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361604/
https://ncbi.nlm.nih.gov/pubmed/25774758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005025
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