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Natural history and therapy of TTR-cardiac amyloidosis: emerging disease-modifying therapies from organ transplantation to stabilizer and silencer drugs

Transthyretin-cardiac amyloidoses (ATTR-CA) are an underdiagnosed but increasingly recognized cause of heart failure. Extracellular deposition of fibrillary proteins into tissues due to a variety of inherited transthyretin mutations in ATTRm or due to advanced age in ATTRwt eventually leads to organ...

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Detalhes bibliográficos
Publicado no:Heart Fail Rev
Main Authors: Castaño, Adam, Drachman, Brian M., Judge, Daniel, Maurer, Mathew S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361302/
https://ncbi.nlm.nih.gov/pubmed/25408161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10741-014-9462-7
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