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A Binding Mode Hypothesis of Tiagabine Confirms Liothyronine Effect on γ-Aminobutyric Acid Transporter 1 (GAT1)

[Image: see text] Elevating GABA levels in the synaptic cleft by inhibiting its reuptake carrier GAT1 is an established approach for the treatment of CNS disorders like epilepsy. With the increasing availability of crystal structures of transmembrane transporters, structure-based approaches to eluci...

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Bibliografische gegevens
Gepubliceerd in:J Med Chem
Hoofdauteurs: Jurik, Andreas, Zdrazil, Barbara, Holy, Marion, Stockner, Thomas, Sitte, Harald H., Ecker, Gerhard F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2015
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360375/
https://ncbi.nlm.nih.gov/pubmed/25679268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5015428
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