Llwytho...

A Binding Mode Hypothesis of Tiagabine Confirms Liothyronine Effect on γ-Aminobutyric Acid Transporter 1 (GAT1)

[Image: see text] Elevating GABA levels in the synaptic cleft by inhibiting its reuptake carrier GAT1 is an established approach for the treatment of CNS disorders like epilepsy. With the increasing availability of crystal structures of transmembrane transporters, structure-based approaches to eluci...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Med Chem
Prif Awduron: Jurik, Andreas, Zdrazil, Barbara, Holy, Marion, Stockner, Thomas, Sitte, Harald H., Ecker, Gerhard F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2015
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360375/
https://ncbi.nlm.nih.gov/pubmed/25679268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5015428
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!