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A Binding Mode Hypothesis of Tiagabine Confirms Liothyronine Effect on γ-Aminobutyric Acid Transporter 1 (GAT1)
[Image: see text] Elevating GABA levels in the synaptic cleft by inhibiting its reuptake carrier GAT1 is an established approach for the treatment of CNS disorders like epilepsy. With the increasing availability of crystal structures of transmembrane transporters, structure-based approaches to eluci...
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| 出版年: | J Med Chem |
|---|---|
| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2015
|
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4360375/ https://ncbi.nlm.nih.gov/pubmed/25679268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5015428 |
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