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Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production

Streptococcus pneumoniae is the most common cause of severe pneumonia in the elderly. However, the impact of aging on the innate inflammatory response to pneumococci is poorly defined. We compared the innate immune response in old vs. young adult mice following infection with S. pneumoniae. The accu...

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Bibliografiske detaljer
Udgivet i:Am J Physiol Lung Cell Mol Physiol
Main Authors: Williams, Andrew E., José, Ricardo J., Brown, Jeremy S., Chambers, Rachel C.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360060/
https://ncbi.nlm.nih.gov/pubmed/25595646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00141.2014
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