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Chronic NOS inhibition accelerates NAFLD progression in an obese rat model

The progression in nonalcoholic fatty liver disease (NAFLD) to nonalcoholic steatohepatitis is a serious health concern, but the underlying mechanisms remain unclear. We hypothesized that chronic inhibition of nitric oxide (NO) synthase (NOS) via N(ω)-nitro-l-arginine methyl ester (l-NAME) would int...

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Pubblicato in:Am J Physiol Gastrointest Liver Physiol
Autori principali: Sheldon, Ryan D., Padilla, Jaume, Jenkins, Nathan T., Laughlin, M. Harold, Rector, R. Scott
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360049/
https://ncbi.nlm.nih.gov/pubmed/25573175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00247.2014
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