β-arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial-mesenchymal transition

Cigarette smoking is a major risk factor in the development of non-small cell lung cancer (NSCLC), which accounts for 80% of all lung cancers. Nicotine, the major addictive component of tobacco smoke, can induce proliferation, invasion and epithelial-mesenchymal transition (EMT) in NSCLC cell lines...

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Publicado en:Cancer Res
Autores principales: Pillai, Smitha, Trevino, Jose, Rawal, Bhupendra, Singh, Sandeep, Kovacs, Michelle, Li, Xueli, Schell, Michael, Haura, Eric, Bepler, Gerold, Chellappan, Srikumar
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359962/
https://ncbi.nlm.nih.gov/pubmed/25600647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0681
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