Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors

Dermal fibroblasts provide a paradigmatic model of cellular adaptation to long-term exogenous stress and ageing processes driven thereby. Here we addressed whether fibroblast ageing analysed ex vivo entails genome instability. Dermal fibroblasts from human female donors aged 20–67 years were studied...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Kalfalah, Faiza, Seggewiß, Sabine, Walter, Regina, Tigges, Julia, Moreno-Villanueva, María, Bürkle, Alexander, Ohse, Sebastian, Busch, Hauke, Boerries, Melanie, Hildebrandt, Barbara, Royer-Pokora, Brigitte, Boege, Fritz
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359693/
https://ncbi.nlm.nih.gov/pubmed/25678531
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