Genetic variability in drug transport, metabolism or DNA repair affecting toxicity of chemotherapy in ovarian cancer

BACKGROUND: This study aimed to determine whether single nucleotide polymorphisms (SNPs) in genes involved in DNA repair or metabolism of taxanes or platinum could predict toxicity or response to first-line chemotherapy in ovarian cancer. METHODS: Twenty-six selected SNPs in 18 genes were genotyped...

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Vydáno v:BMC Pharmacol Toxicol
Hlavní autoři: Lambrechts, Sandrina, Lambrechts, Diether, Despierre, Evelyn, Van Nieuwenhuysen, Els, Smeets, Dominiek, Debruyne, Philip R, Renard, Vincent, Vroman, Philippe, Luyten, Daisy, Neven, Patrick, Amant, Frédéric, Leunen, Karin, Vergote, Ignace
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359565/
https://ncbi.nlm.nih.gov/pubmed/25881102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-015-0001-5
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