The TLR7 agonist induces tumor regression both by promoting CD4(+)T cells proliferation and by reversing T regulatory cell-mediated suppression via dendritic cells

Treg-induced immunosuppression is now recognized as a key element in enabling tumors to escape immune-mediated destruction. Although topical TLR7 therapies such as imiquimod have been proved successful in the treatment of dermatological malignancy and a number of conditions beyond the FDA-approved i...

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Udgivet i:Oncotarget
Main Authors: Wang, Chenchen, Zhou, Quan, Wang, Xiaofeng, Wu, Xiongyan, Chen, Xuehua, Li, Jianfang, Zhu, Zhenggang, Liu, Bingya, Su, Liping
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359331/
https://ncbi.nlm.nih.gov/pubmed/25593198
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