LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients

The PAX5 gene is altered in 30% of BCP-ALL patients and PAX5 chromosomal translocations account for 2–3% of cases. Although PAX5 fusion genes significantly affect the transcription of PAX5 target genes, their role in sustaining leukemia cell survival is poorly understood. In an in vitro model of PAX...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cazzaniga, Valeria, Bugarin, Cristina, Bardini, Michela, Giordan, Marco, te Kronnie, Geertruy, Basso, Giuseppe, Biondi, Andrea, Fazio, Grazia, Cazzaniga, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359315/
https://ncbi.nlm.nih.gov/pubmed/25595912
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