By downregulating Ku80, hsa-miR-526b suppresses non-small cell lung cancer

Ku80 is involved in DNA double-strand breaks (DSBs) repair. Ku80 is overexpressed in lung cancer tissues, yet, molecular mechanisms have not been examined. We identified that miRNA, hsa-miR-526b, is bound to the 3′-UTR of Ku80 mRNA, thus decreasing Ku80 expression in NSCLC cells. Hsa-miR-526b was do...

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Publicat a:Oncotarget
Autors principals: Zhang, Zun-yi, Fu, Sheng-ling, Xu, Su-qin, Zhou, Xiao, Liu, Xian-shen, Xu, Yong-jian, Zhao, Jian-ping, Wei, Shuang
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359307/
https://ncbi.nlm.nih.gov/pubmed/25596743
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