IL-1RT1 signaling antagonizes IL-11 induced STAT3 dependent cardiac and antral stomach tumor development through myeloid cell enrichment

IL-1 is key driver of gastric tumorigenesis and is a downstream target of IL-11 signaling. Recently, IL-1 cytokines, particularly IL-1β, have been flagged as therapeutic targets for gastric cancer treatment. Here, we assess the requirement for IL-1 signaling in gastric tumorigenesis. gp130(757FF) xI...

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Pubblicato in:Oncotarget
Autori principali: Buzzelli, Jon N., Pavlic, Dan I., Chalinor, Heather V., O'Connor, Louise, Menheniott, Trevelyan R., Giraud, Andrew S., Judd, Louise M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359248/
https://ncbi.nlm.nih.gov/pubmed/25528766
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