A NEW ANTIVIRAL: CHIMERIC 3TC-AZT PHOSPHONATE EFFICIENTLY INHIBITS HIV-1 IN HUMAN TISSUES EX VIVO

Although more-recently developed antivirals target different molecules in the HIV-1 replication cycle, nucleoside reverse transcriptase inhibitors (NRTIs) remain central for HIV-1 therapy. Here, we test the anti-HIV activity of a phosphonate chimera of two well-known NRTIs, namely AZT and 3TC. We sh...

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Bibliographic Details
Published in:Antiviral Res
Main Authors: Vanpouille, Christophe, Khandazhinskaya, Anastasia, Karpenko, Inna, Zicari, Sonia, Barreto-de-Souza, Victor, Frolova, Svetlana, Margolis, Leonid, Kochetkov, Sergey
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358798/
https://ncbi.nlm.nih.gov/pubmed/25010891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2014.06.019
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