TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKε supports the anabolic demands of dendritic cell activation

The ligation of Toll-like receptors (TLRs) leads to rapid activation of dendritic cells (DCs). However, the metabolic requirements that support this process remain poorly defined. We found that DC glycolytic flux increased within minutes of exposure to TLR agonists and that this served an essential...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Everts, Bart, Amiel, Eyal, Huang, Stanley Ching-Cheng, Smith, Amber M, Chang, Chih-Hao, Lam, Wing Y, Redmann, Veronika, Freitas, Tori C, Blagih, Julianna, van der Windt, Gerritje J W, Artyomov, Maxim N, Jones, Russell G, Pearce, Erika L, Pearce, Edward J
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358322/
https://ncbi.nlm.nih.gov/pubmed/24562310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2833
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados