TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKε supports the anabolic demands of dendritic cell activation

The ligation of Toll-like receptors (TLRs) leads to rapid activation of dendritic cells (DCs). However, the metabolic requirements that support this process remain poorly defined. We found that DC glycolytic flux increased within minutes of exposure to TLR agonists and that this served an essential...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Immunol
Egile Nagusiak: Everts, Bart, Amiel, Eyal, Huang, Stanley Ching-Cheng, Smith, Amber M, Chang, Chih-Hao, Lam, Wing Y, Redmann, Veronika, Freitas, Tori C, Blagih, Julianna, van der Windt, Gerritje J W, Artyomov, Maxim N, Jones, Russell G, Pearce, Erika L, Pearce, Edward J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358322/
https://ncbi.nlm.nih.gov/pubmed/24562310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2833
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