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Insulin Regulates Retinol Dehydrogenase Expression and All-trans-retinoic Acid Biosynthesis through FoxO1

All-trans-retinoic acid (atRA), an autacoid derived from retinol (vitamin A), regulates energy balance and reduces adiposity. We show that energy status regulates atRA biosynthesis at the rate-limiting step, catalyzed by retinol dehydrogenases (RDH). Six h after re-feeding, Rdh1 expression decreased...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Obrochta, Kristin M., Krois, Charles R., Campos, Benito, Napoli, Joseph L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358144/
https://ncbi.nlm.nih.gov/pubmed/25627686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.609313
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