2-Thiouracil deprived of thiocarbonyl function preferentially base pairs with guanine rather than adenine in RNA and DNA duplexes

2-Thiouracil-containing nucleosides are essential modified units of natural and synthetic nucleic acids. In particular, the 5-substituted-2-thiouridines (S2Us) present in tRNA play an important role in tuning the translation process through codon–anticodon interactions. The enhanced thermodynamic st...

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Publicat a:Nucleic Acids Res
Autors principals: Sochacka, Elzbieta, Szczepanowski, Roman H., Cypryk, Marek, Sobczak, Milena, Janicka, Magdalena, Kraszewska, Karina, Bartos, Paulina, Chwialkowska, Anna, Nawrot, Barbara
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Chemical Biology and Nucleic Acid Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357714/
https://ncbi.nlm.nih.gov/pubmed/25690900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv109
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