Familial and sporadic pancreatic cancer share the same molecular pathogenesis

Pancreatic ductal adenocarcinoma (PDAC) is nearly uniformly lethal, with a median overall survival in 2014 of only 6 months. The genetic progression of sporadic PDAC (SPC) is well established, with common somatic alterations in KRAS, p16/CDKN2A, TP53, and SMAD4/DPC4. Up to 10 % of all PDAC cases occ...

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Detalhes bibliográficos
Publicado no:Fam Cancer
Main Authors: Norris, Alexis L., Roberts, Nicholas J., Jones, Siân, Wheelan, Sarah J., Papadopoulos, Nickolas, Vogelstein, Bert, Kinzler, Kenneth W., Hruban, Ralph H., Klein, Alison P., Eshleman, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357548/
https://ncbi.nlm.nih.gov/pubmed/25240578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10689-014-9755-y
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