Characterization of a Novel Small Molecule That Potentiates β-Lactam Activity against Gram-Positive and Gram-Negative Pathogens

In a loss-of-viability screen using small molecules against methicillin-resistant Staphylococcus aureus (MRSA) strain USA300 with a sub-MIC of a β-lactam, we found a small molecule, designated DNAC-1, which potentiated the effect of oxacillin (i.e., the MIC of oxacillin decreased from 64 to 0.25 μg/...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Nair, Dhanalakshmi R., Monteiro, João M., Memmi, Guido, Thanassi, Jane, Pucci, Michael, Schwartzman, Joseph, Pinho, Mariana G., Cheung, Ambrose L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356822/
https://ncbi.nlm.nih.gov/pubmed/25583731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04164-14
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