Small-Molecule Inhibitors of Staphylococcus aureus RnpA-Mediated RNA Turnover and tRNA Processing

New agents are urgently needed for the therapeutic treatment of Staphylococcus aureus infections. In that regard, S. aureus RNase RnpA may represent a promising novel dual-function antimicrobial target that participates in two essential cellular processes, RNA degradation and tRNA maturation. Accord...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Eidem, Tess M., Lounsbury, Nicole, Emery, John F., Bulger, Jeffrey, Smith, Andrew, Abou-Gharbia, Magid, Childers, Wayne, Dunman, Paul M.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Experimental Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356807/
https://ncbi.nlm.nih.gov/pubmed/25605356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04352-14
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