Glucose and metformin modulate human first trimester trophoblast function:A model and potential therapy for diabetes-associated uteroplacental insufficiency

PROBLEM: Diabetes confers an increased risk of preeclampsia, but its pathogenic role in preeclampsia is poorly understood. The objective of this study was to elucidate the effects of excess glucose on trophoblast function and whether any changes could be reversed by metformin. METHOD OF STUDY: The h...

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Veröffentlicht in:Am J Reprod Immunol
Hauptverfasser: Han, Christina S., Herrin, Melissa A., Pitruzzello, Mary C., Mulla, Melissa J., Werner, Erika F., Pettker, Christian M., Flannery, Clare A., Abrahams, Vikki M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356646/
https://ncbi.nlm.nih.gov/pubmed/25394884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/aji.12339
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