Glucose and metformin modulate human first trimester trophoblast function:A model and potential therapy for diabetes-associated uteroplacental insufficiency

PROBLEM: Diabetes confers an increased risk of preeclampsia, but its pathogenic role in preeclampsia is poorly understood. The objective of this study was to elucidate the effects of excess glucose on trophoblast function and whether any changes could be reversed by metformin. METHOD OF STUDY: The h...

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Detalhes bibliográficos
Publicado no:Am J Reprod Immunol
Main Authors: Han, Christina S., Herrin, Melissa A., Pitruzzello, Mary C., Mulla, Melissa J., Werner, Erika F., Pettker, Christian M., Flannery, Clare A., Abrahams, Vikki M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356646/
https://ncbi.nlm.nih.gov/pubmed/25394884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/aji.12339
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